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Cuphead : As an homage to the trope's common appearance in classic cartoons like Looney Tunes , Djimmi the Great blows a puff of smoke from his pipe shaped like Cuphead with crossed-out eyes as a taunt when he starts the battle

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Higher nicotine concentration in e-cig liquid, as well as use of advanced second-generation e-cigs, which deliver nicotine more efficiently than earlier "cigalikes," predicted dependence